作者
DC Liang, CP Yang, DT Lin, IJ Hung, KH Lin, JS Chen, CC Hsiao, TT Chang, CT Peng, MT Lin, TK Chang, TH Jaing, HC Liu, LY Wang, TC Yeh, ST Jou, MY Lu, CN Cheng, JM Sheen, SS Chiou, KH Wu, GY Hung, RL Chen, SH Chen, SN Cheng, YH Chang, BW Chen, WL Ho, JL Wang, ST Lin, YL Hsieh, SC Wang, HH Chang, YL Yang, FL Huang, CY Chang, WH Chang, KS Lin
发表日期
2010/2
期刊
Leukemia
卷号
24
期号
2
页码范围
397-405
出版商
Nature Publishing Group
简介
The long-term outcome of 1390 children with acute lymphoblastic leukemia (ALL), treated in two successive clinical trials (Taiwan Pediatric Oncology Group (TPOG)-ALL-97 and TPOG-ALL-2002) between 1997 and 2007, is reported. The event-free survival improved significantly (P= 0.0004) over this period, 69.3±1.9% in 1997–2001 to 77.4±1.7% in 2002–2007. A randomized trial in TPOG-97 testing L-asparaginase versus epidoxorubicin in combination with vincristine and prednisolone for remission induction in standard-risk (SR; low-risk) patients yielded similar outcomes. Another randomized trial, in TPOG-2002, showed that for SR patients, two reinduction courses did not improve long-term outcome over one course. Decreasing use of prophylactic cranial irradiation in the period 1997–2008 was not associated with increased rates of CNS relapse, prompting complete omission of prophylactic cranial irradiation …
学术搜索中的文章
DC Liang, CP Yang, DT Lin, IJ Hung, KH Lin, JS Chen… - Leukemia, 2010