作者
Amer Ali Abd El-Hafeez, Hazim O Khalifa, Elham AM Mahdy, Vikas Sharma, Toru Hosoi, Pradipta Ghosh, Koichiro Ozawa, Monica M Montano, Takashi Fujimura, Ahmed RN Ibrahim, Mohamed AA Abdelhamid, Seung Pil Pack, Samia A Shouman, Seiji Kawamoto
发表日期
2019/3
期刊
Pharmacological Reports
卷号
71
页码范围
289-298
出版商
Springer International Publishing
简介
Background
Nor-wogonin, a polyhydroxy flavone, has been shown to possess antitumor activity. However, the mechanisms responsible for its antitumor activity are poorly studied. Herein, we investigated the mechanisms of nor-wogonin actions in triple-negative breast cancer (TNBC) cells.
Methods
Effects of nor-wogonin on cell proliferation and viability of four TNBC cell lines (MDA-MB-231, BT-549, HCC70, and HCC1806) and two non-tumorigenic breast cell lines (MCF-10A and AG11132) were assessed by BrdU incorporation assays and trypan blue dye exclusion tests. Cell cycle and apoptosis analyses were carried out by flow cytometry. Protein expression was analyzed by immunoblotting.
Results
Nor-wogonin significantly inhibited the growth and decreased the viability of TNBC cells; however, it exhibited no or …
学术搜索中的文章
AAA El-Hafeez, HO Khalifa, EAM Mahdy, V Sharma… - Pharmacological Reports, 2019