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We sought to determine whether human skeletal muscle feed arteries (SFMAs) express TRPV₁ channels and what role they play in modulating vascular function.

Human SMFAs do express functional TRPV₁ channels that modulate vascular function, specifically opposing α‐adrenergic receptor‐mediated vasocontraction and potentiating vasorelaxation, in an endothelium‐dependent manner, as evidenced by the α₁‐receptor‐mediated responses. Thus, the vasodilatory role of TRPV₁ channels, and their ligand capsaicin, could be a potential therapeutic target for improving vascular function. Additionally, given the ‘sympatholytic’ effect of TRPV₁ activation and known endogenous activators (anandamide, reactive oxygen species, H⁺, etc.), TRPV₁ channels might contribute to functional sympatholysis during …