作者
Jared M Whitson, Sima P Porten, Joan F Hilton, Janet E Cowan, Nannette Perez, Matthew R Cooperberg, Kirsten L Greene, Maxwell V Meng, Jeff P Simko, Katsuto Shinohara, Peter R Carroll
发表日期
2011/5
期刊
The Journal of urology
卷号
185
期号
5
页码范围
1656-1660
出版商
Wolters Kluwer
简介
Purpose
We assessed whether an association exists between a change in prostate specific antigen and biopsy progression in men on active surveillance.
Materials and Methods
A cohort of patients undergoing active surveillance for prostate cancer was identified from the urological oncology database at our institution. Multivariate logistic regression was performed to determine whether prostate specific antigen velocity, defined as the change in ln(prostate specific antigen) per year, is associated with biopsy progression, defined as a Gleason upgrade or volume progression on repeat biopsy within 24 months of diagnosis.
Results
A total of 241 men with a mean ± SD age of 61 ± 7 years and mean prostate specific antigen 4.9 ± 2.2 ng/ml met study inclusion criteria. Median time to repeat biopsy was 10 months (IQR 6–13). Biopsy progression developed in 55 men (23%), including a Gleason score upgrade in 46 (19 …
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