作者
Ken Chen, Qi Wang, Roy A Pleasants, Long Ge, Wei Liu, Kangning Peng, Suodi Zhai
发表日期
2017/12
来源
BMC infectious diseases
卷号
17
页码范围
1-12
出版商
BioMed Central
简介
Background
The most optimal antifungal agent for empiric treatment of invasive fungal diseases (IFDs) in febrile neutropenia is controversial. Our objective was evaluate the relative efficacy of antifungals for all-cause mortality, fungal infection-related mortality and treatment response in this population.
Methods
Pubmed, Embase and Cochrane Library were searched to identify randomized controlled trials (RCTs). Two reviewers performed the quality assessment and extracted data independently. Pairwise meta-analysis and network meta-analysis were conducted to compare the antifungals.
Results
Seventeen RCTs involving 4583 patients were included. Risk of bias of included studies was moderate. Pairwise meta-analysis indicated the treatment response rate of itraconazole was significantly better than conventional …
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K Chen, Q Wang, RA Pleasants, L Ge, W Liu, K Peng… - BMC infectious diseases, 2017
