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The social illness has become main problem in Indonesia such as drug addiction, prostitution, game addiction, and so on. Based on Indonesian government, through its anti-drug agency, the National Narcotics Board (BNN) in 2015 the number of drug users are 5 million people. Drugs have caused for as many as 15,000 deaths each year in Indonesia. Peoples did not get information about social ills such as the types of drugs that have the same characteristics. As a largest Muslim country in the world may be reduce the social ills with the Islam approach. Recently, the integration of Islamic science and technology has become popular. At times the people get obstacles to get information and advice directly from expert and scholars in Islamic science. This paper is to develop a prototype expert system by providing prevention and best treatment based on Quran and Hadith. We use some of the data for knowledge base …