作者
CM Phelan, J Iqbal, HT Lynch, J Lubinski, J Gronwald, P Moller, P Ghadirian, WD Foulkes, S Armel, A Eisen, SL Neuhausen, L Senter, CF Singer, P Ainsworth, C Kim-Sing, N Tung, M Llacuachaqui, G Chornokur, S Ping, SA Narod
发表日期
2014/1
期刊
British journal of cancer
卷号
110
期号
2
页码范围
530-534
出版商
Nature Publishing Group
简介
Background:
The BRCA1 and BRCA2 genes confer increased susceptibility to breast and ovarian cancer and to a spectrum of other cancers. There is controversy regarding the risk of colorectal cancer conferred by germline mutations in these two genes.
Methods:
We followed 7015 women with a BRCA mutation for new cases of colorectal cancer. Incidence rates in carriers were compared with population-specific incidence rates, and standardised incidence ratios (SIRs) were estimated. The expected numbers of cancers were computed by multiplying person–years at risk by the appropriate age-, sex-and country-specific incidence rates from the five countries.
Results:
Twenty-one incident colorectal cancer cases were observed among all mutation carriers, compared with 23.6 cases expected. The SIR for BRCA1 carriers was 0.92 (95% confidence interval (CI), 0.54–1.40, P= 0.7) and for BRCA2 carriers was 0.82 (95 …
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CM Phelan, J Iqbal, HT Lynch, J Lubinski, J Gronwald… - British journal of cancer, 2014