作者
Hua Shen, Xiaoyi Huang, Jie Min, Shiguan Le, Qing Wang, Xi Wang, Asli A Dogan, Xiangsheng Liu, Pengfei Zhang, Mohamed S Draz, Jian Xiao
发表日期
2019/10/1
来源
Current topics in medicinal chemistry
卷号
19
期号
27
页码范围
2507-2523
出版商
Bentham Science Publishers
简介
The rapid development of nanotechnology has a great influence on the fields of biology, physiology, and medicine. Over recent years, nanoparticles have been widely presented as nanocarriers to help the delivery of gene, drugs, and other therapeutic agents with cellular targeting ability. Advances in the understanding of gene delivery and RNA interference (RNAi)-based therapy have brought increasing attention to understanding and tackling complex genetically related diseases, such as cancer, cardiovascular and pulmonary diseases, autoimmune diseases and infections. The combination of nanocarriers and DNA/RNA delivery may potentially improve their safety and therapeutic efficacy. However, there still exist many challenges before this approach can be practiced in the clinic. In this review, we provide a comprehensive summary on the types of nanoparticle systems used as nanocarriers, highlight the …
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H Shen, X Huang, J Min, S Le, Q Wang, X Wang… - Current topics in medicinal chemistry, 2019