作者
Leonie K Callaway, H David McIntyre, Helen L Barrett, Katie Foxcroft, Anne Tremellen, Barbara E Lingwood, Jacinta M Tobin, Shelley Wilkinson, Alka Kothari, Mark Morrison, Peter O’Rourke, Anita Pelecanos, Marloes Dekker Nitert
发表日期
2019/3/1
期刊
Diabetes Care
卷号
42
期号
3
页码范围
364-371
出版商
American Diabetes Association
简介
OBJECTIVE
Given the role of gut microbiota in regulating metabolism, probiotics administered during pregnancy might prevent gestational diabetes mellitus (GDM). This question has not previously been studied in high-risk overweight and obese pregnant women. We aimed to determine whether probiotics (Lactobacillus rhamnosus and Bifidobacterium animalis subspecies lactis) administered from the second trimester in overweight and obese women prevent GDM as assessed by an oral glucose tolerance test (OGTT) at 28 weeks’ gestation. Secondary outcomes included maternal and neonatal complications, maternal blood pressure and BMI, and infant body composition.
RESEARCH DESIGN AND METHODS
This was a double-blind randomized controlled trial of probiotic versus placebo in overweight and obese pregnant women in Brisbane, Australia.
RESULTS …
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LK Callaway, HD McIntyre, HL Barrett, K Foxcroft… - Diabetes Care, 2019