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There is increasing interest in the potential of artificial intelligence and Big Data (e.g., generated via social media) to help understand economic outcomes. But can artificial intelligence models based on publicly available Big Data identify geographical differences in entrepreneurial personality or culture? We use a machine learning model based on 1.5 billion tweets by 5.25 million users to estimate the Big Five personality traits and an entrepreneurial personality profile for 1772 US counties. The Twitter-based personality estimates show substantial relationships to county-level entrepreneurship activity, accounting for 20% (entrepreneurial personality profile) and 32% (Big Five traits) of the variance in local entrepreneurship, even when controlling for other factors that affect entrepreneurship. Whereas more research is clearly needed, our findings have initial implications for research and practice concerned with …