作者
Srabani Mukherjee, Nuzhat Shaikh, Sushma Khavale, Gayatri Shinde, Pervin Meherji, Nalini Shah, Anurupa Maitra
发表日期
2009/5
期刊
European journal of Endocrinology
卷号
160
期号
5
页码范围
855-862
出版商
Oxford University Press
简介
Objective
Polycystic ovary syndrome (PCOS) is a multigenic disorder, and insulin resistance is one of its hallmark features. Polymorphisms in exon 17 of insulin receptor (INSR) gene are reported to be associated with PCOS. We investigated this association in Indian women and its putative relationship with PCOS associated traits, which has not been explored so far.
Methods
In this case control study, the polymorphisms were investigated by direct sequencing in 180 women with PCOS and 144 age matched controls. Clinical, anthropometric, biochemical, and hormonal parameters were also estimated.
Results
The silent C/T polymorphism at His1058 in exon 17 of INSR was found to be present in our study population. The polymorphic genotype (CT+TT) was significantly associated with PCOS in lean women (χ 2=8.493, df=1, P=0.004). It showed …
学术搜索中的文章
S Mukherjee, N Shaikh, S Khavale, G Shinde… - European journal of Endocrinology, 2009