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In the present study, an attempt was made to study haematological and biochemical changes in bitches affected with Pyometra. Eight bitches with Pyometra (both open and closed type) of six different breeds, mean age 7.6 years (range 5-12 years) were clinically examined and diagnosed for Pyometra. The presumptive clinical diagnosis was based on case history, clinical signs and ultrasonography or radiography or both. The diagnosis was verified by gross examination of a pus-filled uterus during and after the ovariohysterectomy. The blood was collected in sterile test tubes from cephalic vein using 20 gauge needles with all aseptic precautions for haematological study. Total leucocyte count (TLC), differential leucocyte count (DLC), total erythrocyte count (TEC), reticulocyte count and haemoglobin (Hb) concentration were determined for haematology and as biochemical parameters blood urea nitrogen (BUN) and plasma creatinine were estimated to assess the renal dysfunction. Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP) total plasma protein (TP) and albumin was also determined in the pyometric bitches. Haematology of pyometra cases showed leucocytosis, neutrophilia, lymphocytopenia and normocytic and normochromic anemia. Biochemically, the increased BUN and creatinine and hyperproteinemia were observed. Alterations in the haematological and biochemical parameters were more marked in cases where the cervix was closed.