作者
Melissa H Little, Jane Brennan, Kylie Georgas, Jamie A Davies, Duncan R Davidson, Richard A Baldock, Annemiek Beverdam, John F Bertram, Blanche Capel, Han Sheng Chiu, Dave Clements, Luise Cullen-McEwen, Jean Fleming, Thierry Gilbert, Doris Herzlinger, Derek Houghton, Matt H Kaufman, Elena Kleymenova, Peter A Koopman, Alfor G Lewis, Andrew P McMahon, Cathy L Mendelsohn, Eleanor K Mitchell, Bree A Rumballe, Derina E Sweeney, M Todd Valerius, Gen Yamada, Yiya Yang, Jing Yu
发表日期
2007/6/1
期刊
Gene Expression Patterns
卷号
7
期号
6
页码范围
680-699
出版商
Elsevier
简介
Cataloguing gene expression during development of the genitourinary tract will increase our understanding not only of this process but also of congenital defects and disease affecting this organ system. We have developed a high-resolution ontology with which to describe the subcompartments of the developing murine genitourinary tract. This ontology incorporates what can be defined histologically and begins to encompass other structures and cell types already identified at the molecular level. The ontology is being used to annotate in situ hybridisation data generated as part of the Genitourinary Development Molecular Anatomy Project (GUDMAP), a publicly available data resource on gene and protein expression during genitourinary development. The GUDMAP ontology encompasses Theiler stage (TS) 17–27 of development as well as the sexually mature adult. It has been written as a partonomic, text-based …
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