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1. Background

Entrapment neuropathies represent the most prevalent peripheral neuropathy and are the most common cause of neuropathic pain (neuP). Carpal tunnel syndrome (CTS) is the most prevalent entrapment neuropathy with a lifetime risk of∼ 10% that increases to 85% in patients with diabetes. 48 Patients mostly experience tingling and numbness in the hand and loss of dexterity. In addition, some patients experience pain, which can impact on their daily functioning.