作者
Silvia Di-Bonaventura, Josué Fernández-Carnero, Luis Matesanz-García, Alberto Arribas-Romano, Raúl Polli, Andrea and Ferrer-Peña
发表日期
2023/1/5
期刊
Life
卷号
13
期号
1
页码范围
163
出版商
Ke‐Vin Chang
简介
Objective
The main objectives of this review were, firstly, to study the effect of different physiotherapy interventions on BDNF levels, and, secondly, to analyze the influence of physiotherapy on pain levels to subsequently draw conclusions about its possible relationship with BDNF. Background
Based on the theory that neurotrophic factors such as BDNF play a fundamental role in the initiation and/or maintenance of hyperexcitability of central neurons in pain, it was hypothesized that the levels of this neurotrophic factor may be modified by the application of therapeutic interventions, favoring a reduction in pain intensity. Methods
A literature search of multiple electronic databases (Pubmed, PsycINFO, Medline (Ebsco), Scopus, WOS, Embase) was conducted to identify randomized control trials (RCTs) published without language restrictions up to and including March 2022. The search strategy was based on the combination of medical terms (Mesh) and keywords relating to the following concepts: “pain”, “chronic pain”, “brain derived neurotrophic factor”, “BDNF”, “physiotherapy”, and “physical therapy”. A total of seven papers were included. Results
There were two studies that showed statistically significant differences in pain intensity reduction and an increase in the BDNF levels that used therapies such as rTMS and EIMS in patients with chronic myofascial pain. However, the same conclusions cannot be drawn for the other physical therapies applied. Conclusions
rTMS and EIMS interventions achieved greater short-term reductions in pain intensity and increased BDNF over other types of interventions in chronic myofascial pain patients, as …学术搜索中的文章
S Di-Bonaventura, J Fernandez-Carnero… - Life, 2023