查看文章

Objectives: The aim of this study was to evaluate the effect of Emdogain^® (EMD), used for periodontal regeneration, on the growth of periodontal pathogens like Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia. For comparison, we studied the effect of EMD on several microbes associated with other oral diseases as well as its effect on non‐pathogenic oral inhabitants.

Methods: Freshly prepared EMD or its vehicle propylene glycol alginate (PGA) alone were added to calibrated suspensions of microbes. As a control, imitating the post‐surgical subgingival situation after flap closure, a serum/NaCl‐solution mixture was used. Aliquots for growth assays were taken at scheduled times for calculation of colony‐forming units and cell densities over an observation period of 24 h. Additionally, EMD was spotted onto selected, newly seeded microbes growing on agar plates to see if …