作者
Keri N Althoff, Stephen J Gange, Marina B Klein, John T Brooks, Robert S Hogg, Ronald J Bosch, Michael A Horberg, Michael S Saag, Mari M Kitahata, Amy C Justice, Kelly A Gebo, Joseph J Eron, Sean B Rourke, M John Gill, Benigno Rodriguez, Timothy R Sterling, Liviana M Calzavara, Steven G Deeks, Jeffrey N Martin, Anita R Rachlis, Sonia Napravnik, Lisa P Jacobson, Gregory D Kirk, Ann C Collier, Constance A Benson, Michael J Silverberg, Margot Kushel, James J Goedert, Rosemary G McKaig, Stephen E Van Rompaey, Jinbing Zhang, Richard D Moore, North American AIDS Cohort Collaboration on Research and Design
发表日期
2010/6/1
期刊
Clinical infectious diseases
卷号
50
期号
11
页码范围
1512-1520
出版商
The University of Chicago Press
简介
Background . Initiatives to improve early detection and access to human immunodeficiency virus (HIV) services have increased over time. We assessed the immune status of patients at initial presentation for HIV care from 1997 to 2007 in 13 US and Canadian clinical cohorts.
Methods . We analyzed data from 44,491 HIV-infected patients enrolled in the North American-AIDS Cohort Collaboration on Research and Design. We identified first presentation for HIV care as the time of first CD4+ T lymphocyte (CD4) count and excluded patients who prior to this date had HIV RNA measurements, evidence of antiretroviral exposure, or a history of AIDS-defining illness. Trends in mean CD4 count (measured as cells/mm3) and 95% confidence intervals were determined using linear regression adjusted for age, sex, race/ethnicity, HIV transmission risk, and cohort …
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KN Althoff, SJ Gange, MB Klein, JT Brooks, RS Hogg… - Clinical infectious diseases, 2010
