作者
Kate M Dunn, Kathleen W Saunders, Carolyn M Rutter, Caleb J Banta-Green, Joseph O Merrill, Mark D Sullivan, Constance M Weisner, Michael J Silverberg, Cynthia I Campbell, Bruce M Psaty, Michael Von Korff
发表日期
2010/1/19
期刊
Annals of internal medicine
卷号
152
期号
2
页码范围
85-92
出版商
American College of Physicians
简介
Background
Long-term opioid therapy for chronic noncancer pain is becoming increasingly common in community practice. Concomitant with this change in practice, rates of fatal opioid overdose have increased. The extent to which overdose risks are elevated among patients receiving medically prescribed long-term opioid therapy is unknown.
Objective
To estimate rates of opioid overdose and their association with an average prescribed daily opioid dose among patients receiving medically prescribed, long-term opioid therapy.
Design
Cox proportional hazards models were used to estimate overdose risk as a function of average daily opioid dose (morphine equivalents) received at the time of overdose.
Setting
HMO.
Patients
9940 persons who received 3 or more opioid …
引用总数
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