作者
Michael J Silverberg, Chun Chao, Wendy A Leyden, Lanfang Xu, Michael A Horberg, Daniel Klein, William J Towner, Robert Dubrow, Charles P Quesenberry Jr, Romain S Neugebauer, Donald I Abrams
发表日期
2011/12/1
期刊
Cancer Epidemiology, Biomarkers & Prevention
卷号
20
期号
12
页码范围
2551-2559
出版商
American Association for Cancer Research
简介
Background: Few studies have compared cancer risk between HIV-infected individuals and a demographically similar HIV-uninfected internal comparison group, adjusting for cancer risk factors.
Methods: We followed 20,775 HIV-infected and 215,158 HIV-uninfected individuals enrolled in Kaiser Permanente (KP) California for incident cancer from 1996 to 2008. Rate ratios (RR) were obtained from Poisson models comparing HIV-infected (overall and stratified by recent CD4 count and HIV RNA) with HIV-uninfected individuals, adjusted for age, sex, race/ethnicity, calendar period, KP region, smoking, alcohol/drug abuse, and overweight/obesity.
Results: We observed elevated RRs for Kaposi sarcoma (KS; RR = 199; P < 0.001), non-Hodgkin lymphoma (NHL; RR = 15; P < 0.001), anal cancer (RR = 55; P < 0.001), Hodgkin lymphoma (HL; RR = 19; P < 0.001), melanoma (RR = 1.8; P = 0.001), and liver cancer (RR = 1 …
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MJ Silverberg, C Chao, WA Leyden, L Xu, MA Horberg… - Cancer Epidemiology, Biomarkers & Prevention, 2011