作者
Michael Alan Horberg, Michael Jonah Silverberg, Leo Bartemeier Hurley, William James Towner, Daniel Benjamin Klein, Susan Bersoff-Matcha, Winkler Gabriel Weinberg, Diana Antoniskis, Miguel Mogyoros, Wayne Thomas Dodge, Robert Dobrinich, Charles Price Quesenberry, Drew Anthony Kovach
发表日期
2008/3/1
期刊
JAIDS Journal of Acquired Immune Deficiency Syndromes
卷号
47
期号
3
页码范围
384-390
出版商
LWW
简介
Objectives:
To determine the impact of depression on highly active antiretroviral therapy (HAART) adherence and clinical measures and investigate if selective serotonin reuptake inhibitors (SSRIs) improve these measures.
Design:
Retrospective cohort study.
Methods:
In 2 large health maintenance organizations, we measured the effects of depression (with and without SSRI use) on adherence and changes in viral and immunologic control among HIV-infected patients starting a new HAART regimen. HAART adherence, HIV RNA levels, and changes in CD4 T-cell counts through 12 months were measured.
Results:
A total of 3359 patients were evaluated; 42% had a depression diagnosis, and 15% used SSRIs during HAART. Depression without SSRI use was associated with significantly decreased odds of achieving≥ 90% adherence to HAART (odds ratio [OR]= 0.81, 95% confidence interval [CI]: 0.70 to 0.98; P= 0 …
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MA Horberg, MJ Silverberg, LB Hurley, WJ Towner… - JAIDS Journal of Acquired Immune Deficiency …, 2008
