作者
Alaina M Bever, Dong Hang, Xiaosheng He, Amit D Joshi, Ming Ding, Kana Wu, Andrew T Chan, Edward L Giovannucci, Mingyang Song
发表日期
2022/8
期刊
Digestive diseases and sciences
卷号
67
期号
8
页码范围
4078-4085
出版商
Springer US
简介
Background
Higher body mass index (BMI) is associated with increased risk of colorectal cancer. How genetically predicted BMI may be associated with colorectal cancer precursors is unknown.
Aims
Our objective was to quantify the association of genetically predicted and measured BMI with risk of colorectal cancer precursors.
Methods
We evaluated the association of genetically predicted and measured BMI with risk of conventional adenomas, serrated polyps, and synchronous polyps among 27,426 participants who had undergone at least one lower gastrointestinal endoscopy in the Nurses’ Health Study, Nurses’ Health Study II, and Health Professionals Follow-up Study. Genetic risk score was derived from 97 BMI-related single nucleotide polymorphisms. Multivariable logistic regression evaluated each polyp subtype compared to non-polyps.
Results
For conventional adenomas, the OR per 2-kg/m2 increase was …
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