作者
Terry C Jones, Guido Biele, Barbara Mühlemann, Talitha Veith, Julia Schneider, Jörn Beheim-Schwarzbach, Tobias Bleicker, Julia Tesch, Marie Luisa Schmidt, Leif Erik Sander, Florian Kurth, Peter Menzel, Rolf Schwarzer, Marta Zuchowski, Jörg Hofmann, Andi Krumbholz, Angela Stein, Anke Edelmann, Victor Max Corman, Christian Drosten
发表日期
2021/7/9
期刊
Science
卷号
373
期号
6551
页码范围
eabi5273
出版商
American Association for the Advancement of Science
简介
INTRODUCTION
Although post facto studies have revealed the importance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission from presymptomatic, asymptomatic, and mildly symptomatic (PAMS) cases, the virological basis of their infectiousness remains largely unquantified. The reasons for the rapid spread of variant lineages of concern, such as B.1.1.7, have yet to be fully determined.
RATIONALE
Viral load (viral RNA concentration) in patient samples and the rate of isolation success of virus from clinical specimens in cell culture are the clinical parameters most directly relevant to infectiousness and hence to transmission. To increase our understanding of the infectiousness of SARS-CoV-2, especially in PAMS cases and those infected with the B.1.1.7 variant, we analyzed viral load data from 25,381 German cases, including 9519 hospitalized patients, 6110 PAMS cases from walk …
学术搜索中的文章
TC Jones, G Biele, B Mühlemann, T Veith, J Schneider… - Science, 2021