作者
Mario Witkowski, Caroline Tizian, Marta Ferreira-Gomes, Daniela Niemeyer, Terry C Jones, Frederik Heinrich, Stefan Frischbutter, Stefan Angermair, Thordis Hohnstein, Irene Mattiola, Philipp Nawrath, Sophie McEwen, Silvia Zocche, Edoardo Viviano, Gitta Anne Heinz, Marcus Maurer, Uwe Kölsch, Robert Lorenz Chua, Tom Aschman, Christian Meisel, Josefine Radke, Birgit Sawitzki, Jobst Roehmel, Kristina Allers, Verena Moos, Thomas Schneider, Leif Hanitsch, Marcus A Mall, Christian Conrad, Helena Radbruch, Claudia U Duerr, Joseph A Trapani, Emanuela Marcenaro, Tilmann Kallinich, Victor M Corman, Florian Kurth, Leif Erik Sander, Christian Drosten, Sascha Treskatsch, Pawel Durek, Andrey Kruglov, Andreas Radbruch, Mir-Farzin Mashreghi, Andreas Diefenbach
发表日期
2021/12/9
期刊
Nature
卷号
600
期号
7888
页码范围
295-301
出版商
Nature Publishing Group UK
简介
SARS-CoV-2 is a single-stranded RNA virus that causes COVID-19. Given its acute and often self-limiting course, it is likely that components of the innate immune system play a central part in controlling virus replication and determining clinical outcome. Natural killer (NK) cells are innate lymphocytes with notable activity against a broad range of viruses, including RNA viruses,. NK cell function may be altered during COVID-19 despite increased representation of NK cells with an activated and adaptive phenotype,. Here we show that a decline in viral load in COVID-19 correlates with NK cell status and that NK cells can control SARS-CoV-2 replication by recognizing infected target cells. In severe COVID-19, NK cells show defects in virus control, cytokine production and cell-mediated cytotoxicity despite high expression of cytotoxic effector molecules. Single-cell RNA sequencing of NK cells over the time course of …
学术搜索中的文章
M Witkowski, C Tizian, M Ferreira-Gomes, D Niemeyer… - Nature, 2021