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The COVID-19 pandemic has required speech-language pathologists (SLPs) to use telepractice to deliver services. The present study aimed to investigate the knowledge, attitude, and practice (KAP) of SLPs relative to telepractice during the COVID-19 pandemic. This cross-sectional study was carried out during the coronavirus outbreak from July to December 2020. A valid and reliable self-administrated online questionnaire was sent to 600 SLPs who are members of the Iranian Speech Therapy Association. A total of 465 SLPs completed the questionnaire. SLPs who participated in the study had good attitudes toward telepractice (mean 3.99 ± 0.53 on a scale of 1–5). The mean of the knowledge score of the SLPs was 2.66 (±0.73), a value that is considered to be moderate. The mean for the practice score was 2.42 (±0.89), a score that is considered to be seldom to sometimes. Policymakers should take …