作者
Stefan Frantz, Ralph A Kelly, Todd Bourcier
发表日期
2001/2/16
期刊
Journal of Biological Chemistry
卷号
276
期号
7
页码范围
5197-5203
出版商
Elsevier
简介
Growing evidence from patients with heart failure and from experimental animal models implicates effectors of innate immunity in the pathogenesis of this syndrome. The expression of the innate immunity signaling protein, Toll-like receptor 4 (TLR4), is increased in cardiac myocytes in situ and in failing myocardium, but the mechanism by which TLRs may be activated in the failing heart remains unclear. We report that TLR2, which is expressed in cardiac myocytes, participates in the response of these cells to oxidative stress, a major contributor to the pathogenesis of cardiac dysfunction. Hydrogen peroxide increased nuclear factor κB (NF-κB) activation in Chinese hamster ovary fibroblasts that overexpress TLR2 but not in normal or TLR4-overexpressing Chinese hamster ovary cells, an effect that was abrogated by an α-TLR2 antibody. In neonatal rat ventricular myocytes, the α-TLR2 antibody inhibited hydrogen …
引用总数
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S Frantz, RA Kelly, T Bourcier - Journal of Biological Chemistry, 2001