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The historic battle for global polio eradication spanning more than three decades may have reached a decisive juncture in 2021–2022 with wild polio virus cases in single digits in Pakistan and Afghanistan [1]. Despite the unprecedented challenges posed by the coronavirus disease 2019 (COVID-19) pandemic, the remarkable decline in wild poliovirus transmission in the only two remaining polio endemic countries is a testament to the success of strategies implemented by the Global Polio Eradication Initiative (GPEI) to interrupt transmission of the virus with sustained immunization efforts. However, significant challenges remain in the final stretch to achieve the global eradication program’s goal of permanently stopping transmission of all polioviruses everywhere in the world [2]. The surge in circulating vaccine-derived poliovirus (cVDPV) outbreaks across the World Health Organization (WHO) African Region and …