作者
Neil K Viswanathan, Michael E Chirgwin, Julia Gibbs, Brianna N Kalaj, Sierra Durham, Jennifer Tran, Maximillian Gomez, Horacio Lazaro, Ming Chen, Christopher R Mansfield, Emily R Derbyshire, Scott Eagon
发表日期
2023/7/20
期刊
Bioorganic & Medicinal Chemistry Letters
页码范围
129410
出版商
Pergamon
简介
A collection of β-carbolines based on the natural product harmine, a compound known to target the heat shock 90 protein of Plasmodium falciparum, was synthesized and tested for antimalarial activity and potential toxicity. Several of these novel compounds display promising bioactivity, providing a new potential therapeutic with a mode of action that differs versus any currently available clinical treatment.
学术搜索中的文章
NK Viswanathan, ME Chirgwin, J Gibbs, BN Kalaj… - Bioorganic & Medicinal Chemistry Letters, 2023