查看文章

Elucidating the mechanisms which give rise to unique biological functions is a major goal of human biology. Vast quantities of biological data that have been amassed can aid us in understanding these mechanisms, such as at the level of gene expression, protein expression and metabolites, although piecing together these various components can be an arduous undertaking. Though it may be difficult to ascertain the interplay of these entities, living organisms are complex and composed of highly interconnected and interdependent systems, thus requiring system-wide investigations. To that end, the complex interplay of biological entities can be modelled in interaction networks on which various computational approaches can subsequently be applied. In this work, we augment existing network-based approaches and introduce novel ones towards the aim of building a more comprehensive picture of the …