作者
Jianjun Zhang, Haiyan Guo, He Zhang, Haibo Wang, Guanxiang Qian, Xianqun Fan, Andrew R Hoffman, Ji‐Fan Hu, Shengfang Ge
发表日期
2011/1/1
期刊
Cancer
卷号
117
期号
1
页码范围
86-95
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
BACKGROUND
Tumor suppressor microRNA miR‐145 is commonly down‐regulated in colon carcinoma tissues, but its specific role in tumors remains unknown.
METHODS
In this study, the authors identified the Friend leukemia virus integration 1 gene (FLI1) as a novel target of miR‐145. FLI1 is involved in t(11;22)(q24:q12) reciprocal chromosomal translocation in Ewing sarcoma, and its expression appears to be associated with biologically more aggressive tumors.
RESULTS
The authors demonstrated that miR‐145 targets a putative microRNA regulatory element in the 3′‐untranslated region (UTR) of FLI1, and its abundance is reversely associated with FLI1 expression in colon cancer tissues and cell lines. By using a luciferase/FLI1 3′‐UTR reporter system, they found that miR‐145 down‐regulated the reporter activity, and this down‐regulation was reversed by anti–miR‐145. Mutation of the miR‐145 …
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J Zhang, H Guo, H Zhang, H Wang, G Qian, X Fan… - Cancer, 2011