作者
Martin J Batty, Elizabeth B Liddle, Alain Pitiot, Roberto Toro, Madeleine J Groom, Gaia Scerif, Mario Liotti, Peter F Liddle, Tomáš Paus, Chris Hollis
发表日期
2010/3/1
期刊
Journal of the American Academy of Child & Adolescent Psychiatry
卷号
49
期号
3
页码范围
229-238
出版商
Elsevier
简介
OBJECTIVE
Previous studies have shown smaller brain volume and less gray matter in children with attention-deficit/hyperactivity disorder (ADHD). Relatively few morphological studies have examined structures thought to subserve inhibitory control, one of the diagnostic features of ADHD. We examined one such region, the pars opercularis, predicting a thinner cortex of the inferior frontal gyrus (IFG) in children with ADHD.
METHOD
Structural images were obtained from 49 children (24 control; 25 ADHD combined subtype) aged 9 though 15 years. Images were processed using a volumetric pipeline to provide a fully automated estimate of regional volumes of gray and white matter. A further analysis using FreeSurfer provided measures of cortical thickness for each lobe, and for 13 regions in the frontal lobe.
RESULTS
Relative to controls, children with ADHD had smaller whole brain volume and lower gray matter …
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