作者
Chia-Yen Chen, Murray Stein, Robert Ursano, Tianxi Cai, Joel Gelernter, Steven Heeringa, Sonia Jain, Kevin Jensen, Adam Maihofer, Colter Mitchell, Caroline Nievergelt, Matthew Nock, Benjamin Neale, Renato Polimanti, Stephan Ripke, Erin Ware, Susan Borja, Ronald Kessler, Jordan Smoller
发表日期
2017/5/15
期刊
Biological Psychiatry
卷号
81
期号
10
页码范围
S91-S92
出版商
Elsevier
简介
Background
Posttraumatic stress disorder (PTSD) is a serious public health concern. Genome-wide association study (GWAS) of PTSD can provide insight into its etiology. Several GWAS on PTSD diagnosis have been published, including our GWAS on PTSD in the Army Study of Risk and Resilience in Servicemembers (Army STARRS). PTSD is a complex syndrome comprising several symptom domains. To better understand the etiology of PTSD, we performed genome-wide analysis for PTSD symptom domains in Army STARRS.
Methods
We performed genome-wide analysis in 8,920 European American, 1,932 African American, and 2,622 Latino American samples with traumatic experiences. The lifetime severity of three PTSD symptom domains (re-experiencing, avoidance, and hyperarousal) were collected using the PTSD Checklist (abbreviated version). The association analyses were performed using linear …
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CY Chen, M Stein, R Ursano, T Cai, J Gelernter… - Biological Psychiatry, 2017