作者
Rahul Gupta, Masahiro Kanai, Timothy J Durham, Kristin Tsuo, Jason G McCoy, Anna V Kotrys, Wei Zhou, Patrick F Chinnery, Konrad J Karczewski, Sarah E Calvo, Benjamin M Neale, Vamsi K Mootha
发表日期
2024/6/3
期刊
Nature
页码范围
1-1
出版商
Nature Publishing Group UK
简介
When performing a genome-wide association study (GWAS), the choice of which allele (reference vs. alternate) is considered the “effect allele” is arbitrary. In our computations, we chose the reference allele. For a small subset of our results, the effect sizes were erroneously attributed to the alternate allele. The conclusions in our paper are not impacted, as we only use GWAS results to make inferences regarding the presence/absence of associations (ie, using Pvalues). In terms of text, we have corrected one sentence in the main text. In the second sentence of the second paragraph of the subsection “Blood composition influences bulk mtCN” originally reading “… Mendelian randomization showed that effect size loci at GWS for neutrophil count were strongly positively correlated with corresponding…”, the text “positively” should have read “negatively”. This sentence also contains a typographical error that was …
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