作者
Jason V Baker, Kathleen Brummel‐Ziedins, Jacqueline Neuhaus, Daniel Duprez, Nathan Cummins, David Dalmau, Jack DeHovitz, Clara Lehmann, Ann Sullivan, Ian Woolley, Lewis Kuller, James D Neaton, Russell P Tracy, INSIGHT SMART Study Team
发表日期
2013/7/29
期刊
Journal of the American Heart Association
卷号
2
期号
4
页码范围
e000264
简介
Background
HIV infection leads to activation of coagulation, which may increase the risk for atherosclerosis and venous thromboembolic disease. We hypothesized that HIV replication increases coagulation potentially through alterations in extrinsic pathway factors.
Methods and Results
Extrinsic pathway factors were measured among a subset of HIV participants from the Strategies for Management of Anti‐Retroviral Therapy (SMART) trial. Thrombin generation was estimated using validated computational modeling based on factor composition. We characterized the effect of antiretroviral therapy (ART) treatment versus the untreated state (HIV replication) via 3 separate analyses: (1) a cross‐sectional comparison of those on and off ART (n=717); (2) a randomized comparison of deferring versus starting ART (n=217); and (3) a randomized comparison of stopping versus continuing ART (n=500). Compared with viral …
学术搜索中的文章
JV Baker, K Brummel‐Ziedins, J Neuhaus, D Duprez… - Journal of the American Heart Association, 2013