作者
Jennifer N Gelinas, Dion Khodagholy, Thomas Thesen, Orrin Devinsky, György Buzsáki
发表日期
2016/6
期刊
Nature medicine
卷号
22
期号
6
页码范围
641-648
出版商
Nature Publishing Group UK
简介
Interactions between the hippocampus and the cortex are critical for memory. Interictal epileptiform discharges (IEDs) identify epileptic brain regions and can impair memory, but the mechanisms by which they interact with physiological patterns of network activity are mostly undefined. We show in a rat model of temporal lobe epilepsy that spontaneous hippocampal IEDs correlate with impaired memory consolidation, and that they are precisely coordinated with spindle oscillations in the prefrontal cortex during nonrapid-eye-movement (NREM) sleep. This coordination surpasses the normal physiological ripple–spindle coupling and is accompanied by decreased ripple occurrence. IEDs also induce spindles during rapid-eye movement (REM) sleep and wakefulness—behavioral states that do not naturally express these oscillations—by generating a cortical 'down' state. In a pilot clinical examination of four subjects …
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JN Gelinas, D Khodagholy, T Thesen, O Devinsky… - Nature medicine, 2016