作者
Heath R Pardoe, James H Cole, Karen Blackmon, Thomas Thesen, Ruben Kuzniecky, Human Epilepsy Project Investigators
发表日期
2017/7/1
期刊
Epilepsy research
卷号
133
页码范围
28-32
出版商
Elsevier
简介
Objective
We used whole brain T1-weighted MRI to estimate the age of individuals with medically refractory focal epilepsy, and compared with individuals with newly diagnosed focal epilepsy and healthy controls. The difference between neuroanatomical age and chronological age was compared between the three groups.
Methods
Neuroanatomical age was estimated using a machine learning-based method that was trained using structural MRI scans from a large independent healthy control sample (N = 2001). The prediction model was then used to estimate age from MRI scans obtained from newly diagnosed focal epilepsy patients (N = 42), medically refractory focal epilepsy patients (N = 94) and healthy controls (N = 74).
Results
Individuals with medically refractory epilepsy had a difference between predicted brain age and chronological age that was on average 4.5 years older than healthy controls (p = 4.6 × 10 …
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HR Pardoe, JH Cole, K Blackmon, T Thesen… - Epilepsy research, 2017