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Thousands of human diseases could be treated by selectively controlling the expression of specific proteins in vivo. We demonstrate a new series of alkenyl amino alcohol (AAA) ionizable lipids that, when formulated into lipid nanoparticles (LNPs), are capable of delivering human mRNA with unprecedented levels of in vivo efficacy. This study highlights the importance of utilizing synthesis tools in tandem with biological inspiration to understand and improve nucleic acid delivery in vivo.