作者
Philip Shaw, Jason Lerch, Deanna Greenstein, Wendy Sharp, Liv Clasen, Alan Evans, Jay Giedd, F Xavier Castellanos, Judith Rapoport
发表日期
2006/5/1
期刊
Archives of general psychiatry
卷号
63
期号
5
页码范围
540-549
出版商
American Medical Association
简介
Context
Data from a previous prospective study of lobar volumes in children with attention-deficit/hyperactivity disorder (ADHD) are reexamined using a measure of cortical thickness.
Objective
To determine whether regional differences in cortical thickness or cortical changes across time characterize ADHD and predict or reflect its clinical outcome.
Design, Setting, and Participants
Longitudinal study of 163 children with ADHD (mean age at entry, 8.9 years) and 166 controls recruited mainly from a local community in Maryland. Participants were assessed with magnetic resonance imaging. Ninety-seven patients with ADHD (60%) had 2 or more images and baseline and follow-up clinical evaluations (mean follow-up, 5.7 years).
Main Outcome Measures
Cortical thickness across the cerebrum. Patients with ADHD were divided into better and worse outcome groups on the basis of a mean split in scores on the Children's …
引用总数
学术搜索中的文章
P Shaw, J Lerch, D Greenstein, W Sharp, L Clasen… - Archives of general psychiatry, 2006