作者
Philip Shaw, K Eckstrand, W Sharp, J Blumenthal, JP Lerch, DEEA Greenstein, L Clasen, A Evans, J Giedd, JL Rapoport
发表日期
2007/12/4
期刊
Proceedings of the national academy of sciences
卷号
104
期号
49
页码范围
19649-19654
出版商
National Academy of Sciences
简介
There is controversy over the nature of the disturbance in brain development that underpins attention-deficit/hyperactivity disorder (ADHD). In particular, it is unclear whether the disorder results from a delay in brain maturation or whether it represents a complete deviation from the template of typical development. Using computational neuroanatomic techniques, we estimated cortical thickness at >40,000 cerebral points from 824 magnetic resonance scans acquired prospectively on 223 children with ADHD and 223 typically developing controls. With this sample size, we could define the growth trajectory of each cortical point, delineating a phase of childhood increase followed by adolescent decrease in cortical thickness (a quadratic growth model). From these trajectories, the age of attaining peak cortical thickness was derived and used as an index of cortical maturation. We found maturation to progress in a similar …
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P Shaw, K Eckstrand, W Sharp, J Blumenthal, JP Lerch… - Proceedings of the national academy of sciences, 2007