作者
Bernhard Gutmann, Manuel Köckinger, Gabriel Glotz, Tania Ciaglia, Eyke Slama, Matej Zadravec, Stefan Pfanner, Manuel C Maier, Heidrun Gruber-Wölfler, C Oliver Kappe
发表日期
2017
期刊
Reaction Chemistry & Engineering
卷号
2
期号
6
页码范围
919-927
出版商
Royal Society of Chemistry
简介
Herein we present a continuous flow reactor printed from stainless steel by selective laser melting. The reactor was specifically designed for a fast difluoromethylation reaction with nBuLi as base and fluoroform as atom-economic and inexpensive reagent. The reactor features four inlets to allow introduction of substrate, nBuLi, fluoroform, and a final quench solution. The reaction was completed within less than 2 min at −65 °C. The utilization of stainless steel as reactor material is critical to accomplish the heat transfer as well as the chemical and mechanical resistance that is required for this transformation.
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B Gutmann, M Köckinger, G Glotz, T Ciaglia, E Slama… - Reaction Chemistry & Engineering, 2017