作者
Kevin Simon, Desiree Znidar, Gabriel Glotz, Doris Dallinger, C Oliver Kappe
发表日期
2023/12
期刊
Journal of Flow Chemistry
卷号
13
期号
4
页码范围
427-434
出版商
Springer International Publishing
简介
An explorative study on the continuous flow generation of the N-F reagent 2,6-dichloro-1-fluoro-pyridinium tetrafluoroborate from 2-6-dichloropyridine and 10% F2/N2 and its telescoped downstream electrophilic fluorination reaction with an enamine is reported. The 2-step procedure was performed in a modular lab-scale silicon carbide flow reactor, which safely allowed processing corrosive F2 and precise temperature control. Both reaction sequences turned out to be very fast when carried out in flow at − 10 °C: the N-F generation step could be done within 7.9 s and only 6.6 s were necessary for the fluorination of the enamine.
Graphical abstract
学术搜索中的文章
K Simon, D Znidar, G Glotz, D Dallinger, CO Kappe - Journal of Flow Chemistry, 2023