作者
Tian Zhou, Yiming Zheng, Li Sun, Smaranda Ruxandra Badea, Yuanhu Jin, Yang Liu, Alyssa J Rolfe, Haitao Sun, Xi Wang, Zhijian Cheng, Zhaoshuai Huang, Na Zhao, Xin Sun, Jinhua Li, Jianqing Fan, Choogon Lee, Timothy L Megraw, Wutian Wu, Guixue Wang, Yi Ren
发表日期
2019/3
期刊
Nature neuroscience
卷号
22
期号
3
页码范围
421-435
出版商
Nature Publishing Group US
简介
The clearance of damaged myelin sheaths is critical to ensure functional recovery from neural injury. Here we show a previously unidentified role for microvessels and their lining endothelial cells in engulfing myelin debris in spinal cord injury (SCI) and experimental autoimmune encephalomyelitis (EAE). We demonstrate that IgG opsonization of myelin debris is required for its effective engulfment by endothelial cells and that the autophagy–lysosome pathway is crucial for degradation of engulfed myelin debris. We further show that endothelial cells exert critical functions beyond myelin clearance to promote progression of demyelination disorders by regulating macrophage infiltration, pathologic angiogenesis and fibrosis in both SCI and EAE. Unexpectedly, myelin debris engulfment induces endothelial-to-mesenchymal transition, a process that confers upon endothelial cells the ability to stimulate the endothelial …
学术搜索中的文章
T Zhou, Y Zheng, L Sun, SR Badea, Y Jin, Y Liu… - Nature neuroscience, 2019