查看文章

Mycophenolate mofetil is a prodrug of mycophenolic acid (MPA), an immunosuppressive agent used in combination with corticosteroids and calcineurin inhibitors or sirolimus for the prevention of acute rejection after solid organ transplantation. Although MPA has a rather narrow therapeutic window and its pharmacokinetics show considerable intra- and interindividual variability, dosing guidelines recommend a standard dosage regimen of 0.5–1.0g twice daily in adult renal, liver and cardiac transplant recipients. The main objective ofthe present study was to develop a method to predict the MPA area under the plasma concentration-time curve during one 12-hour dosing interval (AUC₁₂) by using multiple linear regression models and maximum aposteriori (MAP) Bayesian estimation methods in patients co-medicated with ciclosporin or sirolimus, aiming to …