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Delayed graft function (DGF) is still a major issue in kidney transplantation. Plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) were evaluated in a population of kidney donors and recipients to investigate their performance to predict early renal function.

Plasma (pNGAL) and urine (uNGAL) samples were obtained from donors before organ procurement, and from recipients before transplantation, and then 6, 24 and 48 h after the procedure. Kidney transplantations were performed from both living donors (LDs, n = 17) and deceased donors (DDs, n = 80). Recovery of renal function was evaluated as the time to reach serum creatinine < 2 mg/l or glomerular filtration rate (GFR) > 40 mL/min. Logistic regression was used to assess the ability of different variables to predict the occurrence of DGF.

Plasma NGAL levels were significantly lower in LDs than in DDs. No …