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The in vitro antiplasmodial activity of seven EtOH extracts and twenty fractions from the partition of the initial ethanolic extracts from seven African medicinal plants used in the Democratic Republic of Congo (DR Congo) for the treatment of malaria was evaluated. The most active EtOH extracts (IC₅₀<3μg/ml) were those from Cassia occidentalis leaves, Euphorbia hirta whole plant, Garcinia kola stem bark and Phyllanthus niruri whole plant. Their respective petroleum ether soluble fractions also exhibited an antiplasmodial activity with IC₅₀<3μg/ml. EtOH extracts from Vernonia amygdalina leaves (5<IC₅₀<10μg/ml), Tetracera poggei leaves (10<IC₅₀<50μg/ml) and Morinda morindoides leaves (50<IC₅₀<100μg/ml) were less active, but their petroleum ether fractions exhibited a pronounced antiplasmodial activity (IC₅₀<3μg/ml). The same observation could also be made for the petroleum ether fraction from Cassia …