作者
Mark A Hlatky, Derek B Boothroyd, Dena M Bravata, Eric Boersma, Jean Booth, Maria M Brooks, Didier Carrié, Tim C Clayton, Nicolas Danchin, Marcus Flather, Christian W Hamm, Whady A Hueb, Jan Kähler, Sheryl F Kelsey, Spencer B King, Andrzej S Kosinski, Neuza Lopes, Kathryn M McDonald, Alfredo Rodriguez, Patrick Serruys, Ulrich Sigwart, Rodney H Stables, Douglas K Owens, Stuart J Pocock
发表日期
2009/4/4
期刊
The lancet
卷号
373
期号
9670
页码范围
1190-1197
出版商
Elsevier
简介
Background
Coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) are alternative treatments for multivessel coronary disease. Although the procedures have been compared in several randomised trials, their long-term effects on mortality in key clinical subgroups are uncertain. We undertook a collaborative analysis of data from randomised trials to assess whether the effects of the procedures on mortality are modified by patient characteristics.
Methods
We pooled individual patient data from ten randomised trials to compare the effectiveness of CABG with PCI according to patients' baseline clinical characteristics. We used stratified, random effects Cox proportional hazards models to test the effect on all-cause mortality of randomised treatment assignment and its interaction with clinical characteristics. All analyses were by intention to treat.
Findings
Ten participating trials provided data on …
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MA Hlatky, DB Boothroyd, DM Bravata, E Boersma… - The lancet, 2009