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Sudden cardiac death (SCD) due to myocardial infarction (MI) is the most common cause of mortality from heart disease. 1 Despite advances in revascularization techniques, the risk of substantial myocardial scarring and ventricular arrhythmias remains high. Unfortunately, the mechanisms that underlie SCD associated with MI are not well understood. As a result, current therapies are largely ineffective. Implantable cardioverter-defibrillators (ICDs) lower mortality, but identification of MI patients who would benefit remains a challenge. Consequently, SCD remains a major unresolved public health problem. This, in part, is what motivated the study by Floré et al 2 reported in this issue of Heart Rhythm, which focuses on methods for predicting SCD in this highly vulnerable patient population.