作者
David M Cash, Gerard R Ridgway, Yuying Liang, Natalie S Ryan, Kirsi M Kinnunen, Thomas Yeatman, Ian B Malone, Tammie LS Benzinger, Clifford R Jack Jr, Paul M Thompson, Bernardino F Ghetti, Andrew J Saykin, Colin L Masters, John M Ringman, Stephen P Salloway, Peter R Schofield, Reisa A Sperling, Nigel J Cairns, Daniel S Marcus, Chengjie Xiong, Randall J Bateman, John C Morris, Martin N Rossor, Sébastien Ourselin, Nick C Fox
发表日期
2013/10/15
期刊
Neurology
卷号
81
期号
16
页码范围
1425-1433
出版商
Lippincott Williams & Wilkins
简介
Objective
To assess regional patterns of gray and white matter atrophy in familial Alzheimer disease (FAD) mutation carriers.
Methods
A total of 192 participants with volumetric T1-weighted MRI, genotyping, and clinical diagnosis were available from the Dominantly Inherited Alzheimer Network. Of these, 69 were presymptomatic mutation carriers, 50 were symptomatic carriers (31 with Clinical Dementia Rating [CDR] = 0.5, 19 with CDR > 0.5), and 73 were noncarriers from the same families. Voxel-based morphometry was used to identify cross-sectional group differences in gray matter and white matter volume.
Results
Significant differences in gray matter (p < 0.05, family-wise error–corrected) were observed between noncarriers and mildly symptomatic (CDR = 0.5) carriers in the thalamus and putamen, as well as in the temporal lobe, precuneus, and cingulate gyrus; the same pattern, but with more extensive …
学术搜索中的文章
DM Cash, GR Ridgway, Y Liang, NS Ryan… - Neurology, 2013