作者
Anadi Mahajan, Justyna Amelio, Kerry Gairy, Gavneet Kaur, Roger A Levy, David Roth, Damon Bass
发表日期
2020/8
来源
Lupus
卷号
29
期号
9
页码范围
1011-1020
出版商
SAGE Publications
简介
Objective
The understanding of systemic lupus erythematosus (SLE) and lupus nephritis (LN) pathogenesis remains incomplete. This review assessed LN development in SLE, within-LN progression and progression to end-stage renal disease (ESRD).
Methods
A keyword-based literature search was conducted, and 26 publications were included.
Results
Overall, 7–31% of patients had LN at SLE diagnosis; 31–48% developed LN after SLE diagnosis, most within 5 years. Class IV was the most commonly found LN class and had the worst prognosis. Histological transformation occurred in 40–76% of patients, more frequently from non-proliferative rather than proliferative lesions. Cumulative 5- and 10-year ESRD incidences in patients with SLE were 3% and 4%, respectively, and 3–11% and 6–19%, respectively, in patients with SLE and LN.
Conclusions
Elevated serum creatinine was identified as a predictor of …
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A Mahajan, J Amelio, K Gairy, G Kaur, RA Levy, D Roth… - Lupus, 2020