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Youth aged 15–17 years are at high risk of tobacco, alcohol and drug use. Given the changing landscape with respect to availability, use of emerging products and regulatory environments, we examined patterns and correlates of polysubstance use among US youth aged 15–17 years.

Cross‐sectional self‐reported data.

United States.

A total of 6127 US youth aged 15–17 years from wave 1 (2013–14) of the nationally representative Population Assessment of Tobacco and Health (PATH) Study.

Latent class analysis was used to identify subgroups of polysubstance use, including 12 tobacco products, alcohol, marijuana, prescription drugs and other drugs. Socio‐demographic characteristics, residence in urban area, sensation‐seeking, sexual orientation and internalizing and externalizing problems were examined as correlates.