作者
Alexander V Sorokin, Anthony F Domenichiello, Amit K Dey, Zhi-Xin Yuan, Aditya Goyal, Shawn M Rose, Martin P Playford, Christopher E Ramsden, Nehal N Mehta
发表日期
2018/7/1
期刊
Journal of Investigative Dermatology
卷号
138
期号
7
页码范围
1518-1528
出版商
Elsevier
简介
Psoriasis is a chronic immune-mediated disease that represents a unique model for investigating inflammation at local and systemic levels. Bioactive lipid mediators (LMs) are potent compounds reported to play a role in the development and resolution of inflammation. Currently, it is not known to what extent these LMs are involved in psoriasis pathophysiology and related metabolic dysfunction. Here, we use targeted and untargeted liquid chromatography-tandem mass spectrometry approaches to quantify LMs in skin and peripheral blood from psoriasis patients and compared them with those of healthy individuals. Lesional psoriasis skin was abundant in arachidonic acid metabolites, as 8-, 12- and 15-hydroxyeicosatetraenoic acid, compared with adjacent nonlesional and skin from healthy individuals. Additionally, a linoleic acid-derived LM, 13-hydroxyoctadecadienoic acid, was significantly increased compared …
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AV Sorokin, AF Domenichiello, AK Dey, ZX Yuan… - Journal of Investigative Dermatology, 2018